Download The Genetics of Alcohol Metabolism

Book Detail
Edition:
Release: 2012-06-24
Publisher:
Binding: Kindle Edition
ISBN/ASIN: B008EFC2DQ
Format: hardcover, kindle, PDF, EPUB

The Genetics of Alcohol Metabolism pdf
Description

The primary enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Both enzymes occur in several forms that are encoded by different genes; moreover, there are variants (i.e., alleles) of some of these genes that encode enzymes with different characteristics and which have different ethnic distributions. Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to date primarily have studied coding variants in the ADH1B, ADH1C, and ALDH2 genes that are associated with altered kinetic properties of the resulting enzymes. For example, certain ADH1B and ADH1C alleles encode particularly active ADH enzymes, resulting in more rapid conversion of alcohol (i.e., ethanol) to acetaldehyde; these alleles have a protective effect on the risk of alcoholism. A variant of the ALDH2 gene encodes an essentially inactive ALDH enzyme, resulting in acetaldehyde accumulation and a prot Download The Genetics of Alcohol Metabolism for free via rapidshare, mediafire, 4shared, dropBox, uploading, fileserve

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