Some Antiviral and Antineoplastic Drugs and other Pharmaceutical Agents (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) Pdf Reviews

Book Detail
Edition: 1
Release: 2000-06
Publisher: World Health Organization
Binding: Paperback
ISBN/ASIN: 9283212762
Format: hardcover, kindle, PDF, EPUB

Some Antiviral and Antineoplastic Drugs and other Pharmaceutical Agents (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) pdf
Description

Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents.

The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and mu Download Some Antiviral and Antineoplastic Drugs and other Pharmaceutical Agents (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) for free via rapidshare, mediafire, 4shared, dropBox, uploading, fileserve

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